Invitrogen™ VPS51 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA590597

Catalog No. PIPA590597

Description

Immunogen sequence: MAAAAAAGPS PGSGPGDSPE GPEGEAPERR RKAHGMLKLY YGLSEGEAAG RPAGPDPLDP TDLNGAHFDP EVYLDKLRRE CPLAQLMDSE TDMVRQIRAL DSDMQTLVYE NYNKFISATD TIRKMKNDFR KMEDEMDRLA TNMAVITDFS ARISATLQDR HERITKLAGV HALLRKLQFL FELPSRLTKC VELGAYGQAV RYQGRAQAVL QQYQHLPSFR AIQDDCQVIT ARLAQQLRQR FREGGSGAPE QAECVELLLA; Positive Samples: A-549; Cellular Location: Golgi apparatus, Recycling endosome, trans-Golgi network.

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.

Specifications

• Antigen: VPS51
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: VPS51
• Gene Alias: 1110014N23Rik; 3110057M17Rik; AI837850; ANG2; ANG3; Another new gene 2 protein; C11orf2; C11orf3; Ffr; PP5382; Protein fat-free homolog; vacuolar protein sorting 51 homolog; vacuolar protein sorting 51 homolog (S. cerevisiae); vacuolar protein sorting-associated protein 51 homolog; VPS51; VPS51 GARP complex subunit; VPS51, GARP complex subunit
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 738
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.55 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q9UID3
• Gene Symbols: VPS51
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human VPS51 (NP_0373972).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG