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Invitrogen™ VPS53 Polyclonal Antibody
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Catalog No. PIPA520549
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100 μg
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Catalog No. Quantity
PIPA520549 100 μg
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Catalog No. PIPA520549 Supplier Invitrogen™ Supplier No. PA520549
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Description

Rabbit Polyclonal Antibody

A suggested positive control is 293 cell lysate. PA5-20549 can be used with blocking peptide PEP-0669.

The sorting of acid hydrolases to lysosomes rely on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintenance of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins. VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in HIV treatment. At least five isoforms of VPS53 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen VPS53
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Vps53
Gene Accession No. Q5VIR6, Q8CCB4
Gene Alias 2010002A08Rik; 2310040I21Rik; 3100002B05Rik; Are1; Hccs1; hVps53L; PCH2E; pp13624; RGD1311391; SAC2 suppressor of actin mutations 2-like protein; Sacm2l; vacuolar protein sorting 52 homolog (S. cerevisiae); vacuolar protein sorting 53 (yeast); vacuolar protein sorting 53 homolog (S. cerevisiae); vacuolar protein sorting-associated protein 52 homolog; Vacuolar protein sorting-associated protein 53 homolog; Vps52; Vps53; VPS53 GARP complex subunit; VPS53, GARP complex subunit
Gene Symbols Vps53
Host Species Rabbit
Immunogen An 18 amino acid peptide from near the center of human VPS53.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 287535, 55275, 68299
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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