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Invitrogen™ VPS53 Polyclonal Antibody
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Catalog No. PIPA555079
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100 μL
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PIPA555079 100 μL
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Catalog No. PIPA555079 Supplier Invitrogen™ Supplier No. PA555079
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ETFQKILDMK GLKRSEQSSM LELLRQRLPA PPSGAESSGS LSLTAPTPEQ ESSRIRKLEK LIK Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 94%.

The sorting of acid hydrolases to lysosomes rely on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintenance of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins. VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in HIV treatment. At least five isoforms of VPS53 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen VPS53
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Vps53
Gene Accession No. Q5VIR6
Gene Alias 2010002A08Rik; 2310040I21Rik; 3100002B05Rik; Are1; Hccs1; hVps53L; PCH2E; pp13624; RGD1311391; SAC2 suppressor of actin mutations 2-like protein; Sacm2l; vacuolar protein sorting 52 homolog (S. cerevisiae); vacuolar protein sorting 53 (yeast); vacuolar protein sorting 53 homolog (S. cerevisiae); vacuolar protein sorting-associated protein 52 homolog; Vacuolar protein sorting-associated protein 53 homolog; Vps52; Vps53; VPS53 GARP complex subunit; VPS53, GARP complex subunit
Gene Symbols Vps53
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human VPS53. Recombinant protein control fragment (Product #RP-93565).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55275
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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