VPS53 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Catalog No.	Quantity
50-172-8277	150 μL

Catalog No. 50-172-8277 Supplier Proteintech Group Inc Supplier No. 128241AP150UL

Description

Rabbit Polyclonal Antibody

The sorting of acid hydrolases to lysosomes rely on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintece of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins. VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in HIV treatment. At least five isoforms of VPS53 are known to exist.

Specifications

• Antigen: VPS53
• Applications: Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 0.13 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: VPS53
• Gene Accession No.: Q5VIR6, Q8CCB4
• Gene Alias: HCCS1, hVps53L, pp13624, VPS53
• Gene Symbols: Vps53
• Host Species: Rabbit
• Immunogen: VPS53 Fusion Protein Ag3518
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 287535, 55275, 68299
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG