Invitrogen™ VPS72 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA536321

Catalog No. PIPA536321

Description

This antibody detects endogenous protein at a molecular weight of 41 kDa. Purity is >95% by SDS-PAGE.

Vacuolar protein sorting-associated protein 72 homolog (VPS72), also known as VPS72 or Transcription factor-like 1, is a 364 amino acid subunit of the TRRAP/TIP60 HAT complex. VPS72 has also been identified as a subunit of a novel complex containing SNF2-related helicase SRCAP (SWI2/SNF2-related CBP activator protein). This SRCAP-containing complex is very similar to the S. cerevisiae SWR1 chromatin remodeling complex. The involvement of VPS72 in these complexes has suggested that VPS72 plays multiple roles in chromatin modification and remodeling in cells. VPS72 localizes to the nucleus and is phosphorylated upon DNA damage, most likely by ATM or ATR.

Specifications

• Antigen: VPS72
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: VPS72
• Gene Alias: CFL1; Protein YL-1; Swc2; T YL-1; TCFL1; Transcription factor-like 1; transformation suppressor gene YL-1; vacuolar protein sorting 72 (yeast); vacuolar protein sorting 72 homolog; vacuolar protein sorting 72 homolog (S. cerevisiae); vacuolar protein sorting-associated protein 72 homolog; VPS72; Yl1; YL-1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21427, 6944
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide; pH 7.2
• Gene Accession No.: Q15906, Q62481
• Gene Symbols: VPS72
• Immunogen: Synthetic peptide corresponding to amino acids 116-168 of human VPS72.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG