VRK1 Monoclonal Antibody (OTI2C9), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA805595

Catalog No. 50-168-0770

Description

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.

Specifications

• Antigen: VRK1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q99986
• Gene Symbols: VRK1
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-230 of human VRK1 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI2C9
• Conjugate: Unconjugated
• Gene: VRK1
• Gene Alias: PCH1, PCH1A
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7443
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid