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  5. Tocris Bioscience™ VT 104

Tocris Bioscience™ VT 104

Catalog No. 817650
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Catalog No. Quantity
81-765-0 50 mg
81-761-0 10 mg
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Catalog No. 81-765-0 Supplier Tocris Bioscience™ Supplier No. 8176/50
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Description

Potent pan-TEAD inhibitor

VT 104 is a potent pan-TEAD (transcriptional enhanced associate domain) inhibitor (IC50 = 10.4 nM). VT 104 inhibits YAP/TAZ-TEAD promoted gene transcription by preventing the association between YAP/TAZ and TEAD. VT 104 blocks TEAD auto-palmitoylation. In vitro, VT 104 inhibits NF2-deficient mesothelioma cell proliferation, and growth of subcutaneous tumor xenografts in vivo. VT 104 is orally bioavailable.

Specifications

Chemical Name or Material N-[(1S)-1-(2-Pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxamide
CAS 2417718-25-1
Quantity 50 mg
Target YAP1
Molecular Formula C25H19F3N2O
Purity 98%
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