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VTCN1 Mouse anti-Human, Clone: 2E5B1, Proteintech
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Catalog No. 501737207 Shop All Proteintech Group Inc Products
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50-173-7207 150 μL
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Catalog No. 50-173-7207 Supplier Proteintech Group Inc Supplier No. 668171IG150UL
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Description

Mouse Monoclonal Antibody

B7-H4 (B7x, VTCN1) a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7-H4 deficient mice are only minimally affected; suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response. B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7-H4 is expressed primarily on the membrane of lymphoid cells, and as an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, it is involved in mediating cellular and humoral immune responses. Overexpression of B7-H4 is associated with certain maligcies, including ovarian and breast cancer, which may be a mechanism by which tumor cells suppress T cell immunity and facilitate tumor progression. Further, VTCN1 may be a useful biomarker for the early detection of ovarian cancer and Renal Cell Carcinoma (RCC).

Specifications

Antigen VTCN1
Applications Western Blot
Classification Monoclonal
Clone 2E5B1
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene VTCN1
Gene Accession No. Q7Z7D3
Gene Alias B7 H4, B7h.5, B7H4, B7S1, B7X, FLJ22418, PRO1291, Protein B7S1, RP11 229A19.4, VCTN1, VTCN1
Gene Symbols VTCN1
Host Species Mouse
Immunogen VTCN1 Fusion Protein Ag27751
Purification Method Protein G
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79679
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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