Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
VTCN1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody
Supplier: Proteintech Group Inc 120801AP150UL

Description
B7-H4 (B7x, VTCN1) a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7-H4 deficient mice are only minimally affected; suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response. B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7-H4 is expressed primarily on the membrane of lymphoid cells, and as an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, it is involved in mediating cellular and humoral immune responses. Overexpression of B7-H4 is associated with certain maligcies, including ovarian and breast cancer, which may be a mechanism by which tumor cells suppress T cell immunity and facilitate tumor progression. Further, VTCN1 may be a useful biomarker for the early detection of ovarian cancer and Renal Cell Carcinoma (RCC).Specifications
VTCN1 | |
Polyclonal | |
Unconjugated | |
VTCN1 | |
B7 H4, B7h.5, B7H4, B7S1, B7X, PRO1291, Protein B7S1, RP11 229A19.4, VCTN1, VTCN1 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
242122, 295322, 79679 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
0.23 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
Q501W4, Q7TSP5, Q7Z7D3 | |
VTCN1 | |
VTCN1 Fusion Protein Ag2712 | |
150 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Product Content Correction
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction