Tocris Bioscience VU 0409551
Selective mGlu5 positive allosteric modulator; brain penetrant and orally bioavailable
Manufacturer: Tocris Bioscience 5693/50
DescriptionSelective mGlu5 positive allosteric modulator (EC50 = 260 nM). Selective for mGlu5 over other mGluR subtypes, as well as 66 other receptors and ion channels. Selectively potentiates mGlu5 signaling via Gαq. Exhibits wake-promoting, antipsychotic-like and cognition-enhancing effects in animal models. Brain penetrant and orally available.
|Target: Group I mGluR Modulators|
Safety and Handling
Recommended Storage : Store at 4°C