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  5. R&D Systems™ VU 0650991

R&D Systems™ VU 0650991
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Catalog No. 635550 Shop All Novus Products
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Catalog No. Quantity
63-555-0 50 mg
63-551-0 10 mg
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Catalog No. 63-555-0 Supplier R&D Systems™ Supplier No. 6355/50

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Description

A Tocris product, part of R&D Systems. Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant

VU 0650991 is a noncompetitive glucagon-like peptide-1 (GLP-1) receptor antagonist (IC50 = 0.65 - 0.69 μM). Displays >40-fold selectivity for GLP-1 receptor over glucagon receptors. Blocks activity of Exendin-4 (Cat. No. 1933) in potentiating insulin secretion from primary mouse pancreatic islets in vitro. Decreases blood insulin and increases blood glucose levels in vivo. Brain penetrant and orally bioavailable.

Specifications

Quantity 50 mg
Product Line Tocris
Molecular Formula C16H11ClF6N4O2
Formula Weight 440.73
Product Type Antagonist
Purity 98%
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