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  5. Tocris Bioscience™ VU 6005649

Tocris Bioscience™ VU 6005649
GREENER_CHOICE

Catalog No. 689310
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Positive allosteric modulators of mGlu7 and mGlu8 receptors. Also NK1 antagonist.

VU 6005649 is a positive allosteric modulator of mGlu7 and mGlu8 receptors (EC50 = 0.65 μM and 2.6 μM for mGlu7 and mGlu8, respectively). Displays >3.8 fold selectivity for mGlu7 and mGlu8 over other mGlu receptors (EC50 >10 μM for mGlu1,2,3,4,5,6). Also NK1 receptor antagonist (Ki= 650 nM, IC50 = 3.4 μM). Brain penetrant.

Specifications

Chemical Name or Material 3-(2,3-Difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 2137047-43-7
Quantity 10 mg
Molecular Formula C16H12F5N3O
Purity 98%
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