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  5. Tocris Bioscience™ VU 6028418 hydrochloride

Tocris Bioscience™ VU 6028418 hydrochloride
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Catalog No. 765810
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Catalog No. Quantity
76-581-0 10 mg
76-585-0 50 mg
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Catalog No. 76-581-0 Supplier Tocris Bioscience™ Supplier No. 7658/10
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Description

Potent and selective M4 mAChR antagonist

VU 6028418 hydrochloride is a potent and selective M4 mAChR antagonist (IC50 = 4.1 nM and 57 nM for human and rat M4 respectively). VU 6028418 hydrochloride dose-dependently reduces the latency to withdraw and reverses cataleptic behavior in haloperidol -treated animals. Orally bioavailable.

Specifications

Chemical Name or Material (3 aR,5 s,6 AS)-2-((Tetrahydro-2 H-pyran-4-yl)methyl)-N-(6-(2,3,5-trifluorophenyl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine hydrochloride
Quantity 10 mg
Target mAChR M4 Antagonists
Molecular Formula C23H27F3N4O.HCl
Purity 0.98
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