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  5. R&D Systems™ VVD-214

R&D Systems™ VVD-214
SDP

Catalog No. RD10188031 Shop All Novus Products
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RD10188031 10 mg
RD10188001 50 mg
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Catalog No. RD10188031 Supplier R&D Systems™ Supplier No. 9027/10

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Description

A Tocris product, part of R&D Systems.

VVD-214 is a potent werner syndrome helicase (WRN) covalent allosteric inhibitor (IC50 = 0.13 μM and 2.4 μM with and without ATP, respectively). The selective binding of VVD-214 to cysteine C727 of WRN triggers double-stranded DNA breaks, nuclear swellings, cell death and tumor regression in microsatellite instability-high (MSI-H) colorectal cancer models. Highly stable in hepatocytes and whole blood, VVD-214 is orally bioavailable.

Specifications

Chemical Name or Material N-[(1S,2E)-1-Cyclopropyl-3-(methylsulfonyl)-2-propen-1-yl]-2-(1,1-difluoroethyl)-4-phenoxy-5-pyrimidinecarboxamide
CAS 3026500-20-6
Quantity 10 mg
Product Line Tocris
Target DNA, RNA and Protein Synthesis Inhibitors
Molecular Formula C20H21F2N3O4S
Purity 98%
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