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R&D Systems™ VVD 844
SDP

Catalog No. RD10188025 Shop All Novus Products
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RD10188025 5 mg
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Catalog No. RD10188025 Supplier R&D Systems™ Supplier No. 8952/5

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Description

A Tocris product, part of R&D Systems. Potent covalent inhibitor of the RAS domain of the PI3K/p110α interaction

VVD 844 is a potent inhibitor of the PI3K/p110α interaction (IC50 = 4 nM) and the phosphorylated-Ser473-AKT (pAKT) pathway (IC50 = 11 nM). It covalently binds cysteine 242 in the RAS domain of PI3K/p110α and blocks RAS activation of PI3Kα activity in vitro.

In vivo, VVD 844 slows growth of RAS mutant tumors and human epidermal growth factor receptor 2 (HER2)-overexpressing tumors, without causing hyperglycemia. Exhibits synergistic effects with Sotorasib (Cat. No. 7713) and Adagrasib (Cat. No. 7488). VVD 844 is orally bioavailable.

Specifications

Chemical Name or Material 5-((1R,2S,5S)-2-(2-Chloro-3-fluorophenyl)-3-azabicyclo[3.1.0]hexan-3-yl)-N-((R,E)-4-(methylsulfonyl)but-3-en-2-yl)pyrazine-2-carboxamide
CAS 3080226-63-4
Quantity 5 mg
Product Line Tocris
Target GTPase Inhibitors
Molecular Formula C21H22ClFN4O3S
Purity 98%
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