VWF Monoclonal Antibody (OTI2D10), TrueMAB™, OriGene

Catalog No.	Quantity
50-167-9651	100 μL

Catalog No. 50-167-9651 Supplier OriGene Supplier No. TA803260

Description

Mouse Monoclonal Antibody

Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein, which binds to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. It is synthesized by endothelial cells and stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls and serves as a carrier and stabilizer for coagulation factor VIII. von Willebrand factor is one of the most useful markers to identify endothelial (or megakaryocytic) lineage of neoplasms. As not all endothelial cells synthesize/ store) this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or maligt. Staining for factor VIII related antigen has also been used to measure angiogenesis, an indicator of tumor recurrence.

Specifications

• Antigen: VWF
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: OTI2D10
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: VWF
• Gene Accession No.: P04275
• Gene Alias: F8VWF, VWD
• Gene Symbols: VWF
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 764-1263 of human VWF produced in SF9 cell.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7450
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1