VWF Mouse anti-Human, Clone: OTI8F10, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF803689

Catalog No. 50-166-6629

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein, which binds to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. It is synthesized by endothelial cells and stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls and serves as a carrier and stabilizer for coagulation factor VIII. von Willebrand factor is one of the most useful markers to identify endothelial (or megakaryocytic) lineage of neoplasms. As not all endothelial cells synthesize/ store) this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or maligt. Staining for factor VIII related antigen has also been used to measure angiogenesis, an indicator of tumor recurrence.

Specifications

• Antigen: VWF
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: VWF
• Gene Alias: F8VWF, VWD
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7450
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI8F10
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P04275
• Gene Symbols: VWF
• Immunogen: Human recombit protein fragment corresponding to amino acids 764-1263 of human VWF produced in SF9 cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b