Invitrogen™ WAC Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA557705

Catalog No. PIPA557705

Description

Immunogen sequence: RLSDGCHDRR GDSQPYQALK YSSKSHPSSG DHRHEKMRDA GDPSPPNKML RRSDSPENKY SDSTGHSKAK NVHTHRVRER DGGTSYSPQE NSH Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 91%.

The WW domain containing adaptor with coiled-coil protein (WAC) contains a WW domain that mediates protein-protein interactions and colocalizes with RNA splicing factor SC35. Further studies have indicated that WAC is a functional partner of the RNF20/40 complex that ubiquitinates Histone H2B, and that WAC regulates H2B ubiquitination. WAC targets RNF20/40 to associate with RNA polymerase II complex for H2B ubiquitination at active transcription sites. WAC-dependent transcription is also important for cell-cycle checkpoint activation in response to genotoxic stress.

Specifications

• Antigen: WAC
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Wac
• Gene Alias: 1110067P07Rik; A230035H12Rik; AI256735; AI256776; BM-016; DESSH; Kiaa1844; PRO1741; RGD1562407; Wac; WW domain containing adaptor with coiled-coil; WW domain-containing adapter protein with coiled-coil; WW domain-containing adaptor with coiled-coil; WW domain-containing protein 4; Wwp4
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51322
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9BTA9
• Gene Symbols: Wac
• Immunogen: Recombinant protein corresponding to Human WAC. Recombinant protein control fragment (Product #RP-97019).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov