Invitrogen™ WASH2P Polyclonal Antibody

Catalog No.	Quantity
PA549182	400 μL

Catalog No. PA549182 Supplier Invitrogen™ Supplier No. PA549182

Description

Rabbit Polyclonal Antibody

Predicted to react with bovine, mouse and rat based on sequence homology.

Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity. [UniProt].

Specifications

• Antigen: WASH2P
• Applications: Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene: WASH2P
• Gene Accession No.: Q6VEQ5
• Gene Alias: FAM39B; Protein FAM39B; WAS protein family homolog 2 pseudogene; WASH2P
• Gene Symbols: WASH2P
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human WASH2P.
• Purification Method: Antigen affinity chromatography, Protein A
• Quantity: 400 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 375260
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov