Invitrogen™ WASP Polyclonal Antibody

Catalog No.	Quantity
PIPA580224	100 μg

Catalog No. PIPA580224 Supplier Invitrogen™ Supplier No. PA580224

Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human HL-60 whole cell, human U937 whole cell, human Jurkat whole cell, human MCF-7 whole cell, rat liver tissue, mouse RAW2647 cell. IHC: human lung cancer tissue IHC-F: human placenta tissue. ICC/IF: a549 cell.

The Wiskott-Aldrich syndrome family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.

Specifications

• Antigen: WASP
• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 500 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 5mg BSA and 0.05mg sodium azide
• Gene: Was
• Gene Accession No.: P42768, P70315
• Gene Alias: 2900021I12Rik; 3110031I02Rik; eczema-thrombocytopenia; IMD2; neural Wiskott-Aldrich syndrome protein; NWASP; N-WASP; SCNX; THC; THC1; thrombocytopenia 1 (X-linked); TRS4; U42471; Was; WASL; Wasp; WASPA; WASPB; Wiskott-Aldrich syndrome; Wiskott-Aldrich syndrome homolog; Wiskott-Aldrich syndrome homolog (human); Wiskott-Aldrich syndrome like; wiskott-Aldrich syndrome protein; Wiskott-Aldrich syndrome protein homolog; Wiskott-Aldrich syndrome-like; Wiskott-Aldrich syndrome-like (human)
• Gene Symbols: Was
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human WASP (129-156aa ADEDEAQAFRALVQEKIQKRNQRQSGDR).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 22376, 317371, 7454
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG