Invitrogen™ WBSCR22 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA562566

Catalog No. PIPA562566

Description

Immunogen sequence: ELFYDETEAR KYVRNSRMID IQTRMAGRAL ELLYLPENKP CYLLDIGCGT GLSGSYLSDE GHYWVGLDIS PAMLDE Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 80%.

The WBSCR22 gene, also known as Williams-Beuren Syndrome Chromosome Region 22, encodes a protein that participates in the biogenesis of the 40S ribosomal subunit. This gene is one of the 26 deleted in Williams-Beuren syndrome, which is characterized by cognitive delays, congenital heart and vascular diseases, and distinct facial features. WBSCR22 features a nuclear localization signal and an S-adenosylmethionine (SAM) binding motif typical of methyltransferases. The protein enhances cell survival and proliferation, with increased expression linked to poor prognosis in various cancers, including glioma and breast cancer. WBSCR22 modulates key signaling pathways such as Akt/GSK3B and beta-catenin/CyclinD1, and is a direct target of miR-146b-5p. Moreover, its downregulation suppresses tumor growth, suggesting its potential as a therapeutic target in oncology.

Specifications

• Antigen: WBSCR22
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BUD23
• Gene Alias: 1110003N24Rik; Bud site selection protein 23 homolog; BUD23; HASJ4442; HUSSY-03; HUSSY-3; MERM1; Metastasis-related methyltransferase 1; PP3381; Probable 18S rRNA (guanine-N(7))-methyltransferase; ribosome biogenesis methyltransferase WBSCR22; rRNA methyltransferase and ribosome maturation factor; WBMT; WBSCR22; Williams Beuren syndrome chromosome region 22; Williams-Beuren candidate region putative methyltransferase; Williams-Beuren syndrome chromosomal region 22 protein; Williams-Beuren syndrome chromosomal region 22 protein homolog; Williams-Beuren syndrome chromosome region 22
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114049
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O43709
• Gene Symbols: BUD23
• Immunogen: Recombinant protein corresponding to Human WBSCR22. Recombinant protein control fragment (Product #RP-92623).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG