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Invitrogen™ WBSCR22 Polyclonal Antibody
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Catalog No. PIPA562566
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100 μL
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PIPA562566 100 μL
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Catalog No. PIPA562566 Supplier Invitrogen™ Supplier No. PA562566
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ELFYDETEAR KYVRNSRMID IQTRMAGRAL ELLYLPENKP CYLLDIGCGT GLSGSYLSDE GHYWVGLDIS PAMLDE Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 80%.

The WBSCR22 gene, also known as Williams-Beuren Syndrome Chromosome Region 22, encodes a protein that participates in the biogenesis of the 40S ribosomal subunit. This gene is one of the 26 deleted in Williams-Beuren syndrome, which is characterized by cognitive delays, congenital heart and vascular diseases, and distinct facial features. WBSCR22 features a nuclear localization signal and an S-adenosylmethionine (SAM) binding motif typical of methyltransferases. The protein enhances cell survival and proliferation, with increased expression linked to poor prognosis in various cancers, including glioma and breast cancer. WBSCR22 modulates key signaling pathways such as Akt/GSK3B and beta-catenin/CyclinD1, and is a direct target of miR-146b-5p. Moreover, its downregulation suppresses tumor growth, suggesting its potential as a therapeutic target in oncology.
TRUSTED_SUSTAINABILITY

Specifications

Antigen WBSCR22
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene BUD23
Gene Accession No. O43709
Gene Alias 1110003N24Rik; Bud site selection protein 23 homolog; BUD23; HASJ4442; HUSSY-03; HUSSY-3; MERM1; Metastasis-related methyltransferase 1; PP3381; Probable 18S rRNA (guanine-N(7))-methyltransferase; ribosome biogenesis methyltransferase WBSCR22; rRNA methyltransferase and ribosome maturation factor; WBMT; WBSCR22; Williams Beuren syndrome chromosome region 22; Williams-Beuren candidate region putative methyltransferase; Williams-Beuren syndrome chromosomal region 22 protein; Williams-Beuren syndrome chromosomal region 22 protein homolog; Williams-Beuren syndrome chromosome region 22
Gene Symbols BUD23
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human WBSCR22. Recombinant protein control fragment (Product #RP-92623).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114049
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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