Invitrogen™ WDR35 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA560629

Catalog No. PIPA560629

Description

Immunogen sequence: SLPNVGLIQK YSLNCRAYQL SLNCNSSRLA IIDISGVLTF FDLDARVTDS TGQQVVGELL KLERRDVWDM KWAKDNPDLF AMMEKTRMYV FRNLDPEEPI QTSGY Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.

WD40 repeats are a common structural module in eukaryotic proteins, and proteins containing WD40 domains have a wide range of functions, including signal transduction, cell cycle regulation, RNA splicing, and transcription. One such protein, WDR35, also known as CED2, has been shown to be mutated in patients with Sensenbrenner syndrome/cranioectodermal dysplasia (CED), an autosomal-recessive disease that is characterized by craniosynstosis and ectodermal and skeletal abnormalities. WDR35 localizes to cilia and dentrosomes during embryogenesis and human and mouse fibroblasts that lack this gene fail to produce cilia. Mutations in this gene can also cause short-rib polydactyly syndromes due to abnormal ciliogenesis.

Specifications

• Antigen: WDR35
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: WDR35
• Gene Alias: 4930459M12Rik; 4931430C06; CED2; IFT121; IFTA1; intraflagellar transport protein 121 homolog; KIAA1336; mKIAA1336; Naofen; RGD1564116; SRTD7; WD repeat domain 35; WD repeat domain 35-like; WD repeat-containing protein 35; WDR35; Wdr35l
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57539
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9P2L0
• Gene Symbols: WDR35
• Immunogen: Recombinant protein corresponding to Human WDR35. Recombinant protein control fragment (Product #RP-99642).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG