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Invitrogen™ WDR41 Monoclonal Antibody (1F3)
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Catalog No. PIMA522129
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100 μg
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PIMA522129 100 μg
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Catalog No. PIMA522129 Supplier Invitrogen™ Supplier No. MA522129
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Description

Mouse Monoclonal Antibody

Peptide Sequence: MLRWLIGGGR EPQGLAEKSP LQTIGEEQTQ NPYTELLVLK AHHDIVRFLV QLDDYRFASA GDDGIVVVWN AQTGEKLLEL NGHTQKITAI ITFPSLESCE EKNQLILTAS ADRTVIVWDG DTTRQVQRIS CFQSTVKCLT VLQRLDVWLS GGNDLCVWNR KLDLLCKTSH LSDTGISALV EIPKNCVVAA VGKELIIFRL VAPTEGSLEW DILEVKRLLD HQDNILSLIN VNDLSFVTGS HVGELIIWDA LDWTMQAYER NFWDPSPQLD TQQEIKLCQK SNDISIHHFT CDEENVFAAV GRGLYVYSLQ MKRVIACQKT AHDSNVLHVA RLPNRQLISC SEDGSVRIWE LREKQQLAAE PVPTGFFNMW GFGRVSKQAS QPVKKQQENA TSCSLELIGD LIGHSSSVEM FLYFEDHGLV TCSADHLIIL WKNGERESGL RSLRLFQKLE ENGDLYLAV.

Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen WDR41
Applications ELISA, Western Blot
Classification Monoclonal
Clone 1F3
Concentration 0.2-1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene WDR41
Gene Accession No. Q9HAD4
Gene Alias B830029I03Rik; MSTP048; WD repeat domain 41; WD repeat-containing protein 41; WDR41
Gene Symbols WDR41
Host Species Mouse
Immunogen WDR41 (AAH40241, 1 a.a. ~ 459 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55255
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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