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Invitrogen™ WDR41 Monoclonal Antibody (A9C10)
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Catalog No. FEMA550619
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100 μL
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Catalog No. Quantity
FEMA550619 100 μL
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Catalog No. FEMA550619 Supplier Invitrogen™ Supplier No. MA550619
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Description

Mouse Monoclonal Antibody

Positive control: Daudi cell lysate, SiHa cell lysate, rat kidney tissue, human testis tissue, human colon tissue, Hela. Predicted band size: 52 kDa Subcellular Location: Cytoplasm.

Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen WDR41
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone A9C10
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene WDR41
Gene Accession No. Q9HAD4
Gene Alias B830029I03Rik; MSTP048; WD repeat domain 41; WD repeat-containing protein 41; WDR41
Gene Symbols WDR41
Host Species Mouse
Immunogen Recombinant protein within human aa 231-430/459.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 361879, 55255
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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