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Invitrogen™ WDR41 Polyclonal Antibody
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Catalog No. PIPA524352
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400 μL
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PIPA524352 400 μL
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Catalog No. PIPA524352 Supplier Invitrogen™ Supplier No. PA524352
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Description

Rabbit Polyclonal Antibody

WDR41 Polyclonal Antibody for Western Blot, IHC (P)

Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen WDR41
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene WDR41
Gene Accession No. Q3UDP0, Q9HAD4
Gene Alias B830029I03Rik; MSTP048; WD repeat domain 41; WD repeat-containing protein 41; WDR41
Gene Symbols WDR41
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 249-277 amino acids from the C-terminal region of human WDR41.
Purification Method Antigen Affinity Chromatography, Protein A
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 218460, 55255
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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