Invitrogen™ WDR59 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA559420

Catalog No. PIPA559420

Description

Immunogen sequence: TSSQDNSVKF WDYRQPRKYL NILPCQVPVW KARYTPFSNG LVTVMVPQLR RENSLLLWNV FDLNTPVHTF VGHDDVVLEF QWRKQKEGSK D Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 99%.

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). [UniProt].

Specifications

• Antigen: WDR59
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: WDR59
• Gene Alias: FP977; GATOR complex protein WDR59; KIAA1923; WD repeat domain 59; WD repeat-containing protein 59; WDR59
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 79726
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6PJI9
• Gene Symbols: WDR59
• Immunogen: Recombinant protein corresponding to Human WDR59. Recombinant protein control fragment (Product #RP-98626).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov