Invitrogen™ WDYHV1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA565814

Catalog No. PIPA565814

Description

Immunogen sequence: RPGDGPVIWDY HVVLLHVSSG GQNFIYDLDT VLPFPCLFDT YVEDAFKSDD DIHPQFRRKF RVIRADS Highest antigen sequence identity to the following orthologs - mouse 82%, rat 84%.

WDYHV1 mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.

Specifications

• Antigen: WDYHV1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: WDYHV1
• Gene Alias: 2410187C16Rik; AU014961; AW550036; C8orf32; nt(Q)-amidase; Ntaq1; N-terminal Gln amidase; protein NH2-terminal glutamine deamidase; Protein N-terminal glutamine amidohydrolase; WDYHV motif containing 1; WDYHV motif-containing protein 1; WDYHV1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55093
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96HA8
• Gene Symbols: WDYHV1
• Immunogen: Recombinant Human WDYHV1. Recombinant protein control fragment (Product #RP-106487).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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