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Invitrogen™ WEE2 Polyclonal Antibody
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Catalog No. PIPA5140078
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100 μL
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PIPA5140078 100 μL
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Catalog No. PIPA5140078 Supplier Invitrogen™ Supplier No. PA5140078
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Description

Rabbit Polyclonal Antibody

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: DIDKELRQKL NFSYCEETEI EGQKKVEESR EASSQTPEKG EVQDSEAKGT PPWTPLSNVH ELDTSSEKDK ESPDQILRTP VSHPLKC Highest antigen sequence indentity to the following orthologs: Rat - 41%, Mouse - 43%.

Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II (PubMed:29606300). Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen WEE2
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene WEE2
Gene Accession No. P0C1S8
Gene Alias Gm1065; mWee1B; WEE1 homolog 2 (S. pombe); WEE1B; Wee1B kinase; wee1-like protein kinase 1B; Wee1-like protein kinase 2; Wee2
Gene Symbols WEE2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human WEE2. Recombinant protein control fragment (Product #RP-108910).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 494551
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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