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WEE2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA548699

Catalog No. PA548699

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at  ft.Tyr-15 ft., leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at  ft.Tyr-15 ft., to ensure exit from meiosis in oocytes and promote pronuclear formation.
Specifications

Specifications

Wee2
Polyclonal
PBS with 0.09% sodium azide
P0C1S8, Q66JT0
Wee1-like protein kinase 2, Wee1-like protein kinase 1B, Wee1B kinase, mWee1B, Wee2, Wee1b
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
381759, 494551
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
WEE2
Liquid
WEE2
KLH conjugated synthetic peptide between 364-393 amino acids from the Central region of mouse Wee2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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