WEE2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA548699
DescriptionOocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at ft.Tyr-15 ft., leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at ft.Tyr-15 ft., to ensure exit from meiosis in oocytes and promote pronuclear formation.
|PBS with 0.09% sodium azide|
|Wee1-like protein kinase 2, Wee1-like protein kinase 1B, Wee1B kinase, mWee1B, Wee2, Wee1b|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|KLH conjugated synthetic peptide between 364-393 amino acids from the Central region of mouse Wee2.|
|Antigen affinity chromatography|
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