WEE2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA548699

Catalog No. PA548699

Description

Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at ′Tyr-15′, leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at ′Tyr-15′, to ensure exit from meiosis in oocytes and promote pronuclear formation.

Specifications

• Antigen: Wee2
• Classification: Polyclonal
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: P0C1S8, Q66JT0
• Gene Symbols: WEE2
• Immunogen: KLH conjugated synthetic peptide between 364-393 amino acids from the Central region of mouse Wee2.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Gene: WEE2
• Gene Alias: Wee1-like protein kinase 2, Wee1-like protein kinase 1B, Wee1B kinase, mWee1B, Wee2, Wee1b
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 381759, 494551
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid