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WHI-P 154

Catalog No. 311525
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Quantity:
5 mg
25 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

JAK3 kinase inhibitor. Also inhibits EGFR

WHI-P 154 is a JAK3 inhibitor (IC50 = 1.8 μM) that displays no activity at JAK1 or JAK2. Inhibits STAT1 activation, iNOS expression and NO production in macrophages in vitro. Also inhibits other common kinases including EGFR (IC50 = 4 nM), Src, Abl, VEGFR, MAPK and PI 3-K and induces apoptosis in human glioblastoma cell lines (IC50 = 158 μM). Induces differentiation of neural progenitor cells.

Specifications

Chemical Name or Material 2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol
CAS 211555-04-3
Assay Percent Range >99%
Quantity 25 mg
Molecular Formula C16H14BrN3O3
Formula Weight Observed MW: 376.2
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