Invitrogen™ WHIP Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA556847

Catalog No. PIPA556847

Description

Immunogen sequence: YQGCHFIGMP ECEVLLAQCV VYFARAPKSI EVYSAYNNVK ARLRNHQGPL PPVPLHLRNA PTRLMKDLGY G Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.

Specifications

• Antigen: WHIP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: WRNIP1
• Gene Alias: 4833444L21Rik; ATPase WRNIP1; bA420G6.2; FLJ22526; putative helicase RUVBL; RP11-420G6.2; UniProtKB:Q96S55}; Werner helicasae interacting protein 1; Werner helicase interacting protein 1; Werner helicase-interacting protein 1; Werner syndrome homolog interacting protein; Whip; Wrnip; Wrnip1; wrnip1 {ECO:0000250
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 56897
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96S55
• Gene Symbols: WRNIP1
• Immunogen: Recombinant protein corresponding to Human WHIP. Recombinant protein control fragment (Product #RP-94744).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG