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Invitrogen™ WHIP Polyclonal Antibody
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Catalog No. PIPA5141987
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100 μg
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PIPA5141987 100 μg
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Catalog No. PIPA5141987 Supplier Invitrogen™ Supplier No. PA5141987
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Description

Goat Polyclonal Antibody

Additional Information: This antibody is expected to recognise isoform 1 (NP_064520.2) and isoform 2 (NP_569079.1). This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen WHIP
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene WRNIP1
Gene Accession No. Q96S55
Gene Alias 4833444L21Rik; ATPase WRNIP1; bA420G6.2; FLJ22526; putative helicase RUVBL; RP11-420G6.2; UniProtKB:Q96S55}; Werner helicasae interacting protein 1; Werner helicase interacting protein 1; Werner helicase-interacting protein 1; Werner syndrome homolog interacting protein; Whip; Wrnip; Wrnip1; wrnip1 {ECO:0000250
Gene Symbols WRNIP1
Host Species Goat
Immunogen Peptide with sequence EELRGVDFFKQRRC.
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56897
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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