WHIPRabbit anti-Human, Monkey, Mouse, Rat, Polyclonal, Rockland™

Catalog No.	Quantity
50-199-1787	100 μg

Catalog No. 50-199-1787 Supplier Rockland Immunochemicals Supplier No. 600401676

Description

Rabbit Polyclonal Antibody

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Reactivity is expected against human, mouse, rat and monkey WHIP1 protein.

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.

Specifications

• Antigen: WHIP
• Applications: ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
• Gene: WRNIP1
• Gene Accession No.: Q8CG07, Q91XU0, Q96S55
• Gene Alias: 4833444L21Rik; ATPase WRNIP1; bA420G6.2; FLJ22526; putative helicase RUVBL; RP11-420G6.2; UniProtKB:Q96S55}; Werner helicasae interacting protein 1; Werner helicase interacting protein 1; Werner helicase-interacting protein 1; Werner syndrome homolog interacting protein; WHIP; Wrnip; Wrnip1; wrnip1 {ECO:0000250
• Gene Symbols: WRNIP1
• Host Species: Rabbit
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 282835, 56897, 78903
• Target Species: Human, Monkey, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid