Invitrogen™ WHSC2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA565373

Catalog No. PIPA565373

Description

Immunogen sequence: DTGSLNLELEE QNPNVQDILG ELREKVGECE ASAMLPLECQ YLNKNALTTL AGPLTPPVKH FQLKRKPKSA TLRAELLQKS TET Highest antigen sequence identity to the following orthologs - mouse 98%, rat 98%.

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

Specifications

• Antigen: WHSC2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NELFA
• Gene Alias: FLJ10442; FLJ25112; LOW QUALITY PROTEIN: negative elongation factor A; mWHSC2; Negative elongation factor A; negative elongation factor complex member A; negative elongation factor complex member A, Whsc2; Nelfa; NELF-A; P/OKcl.15; Whsc2; Whsc2h; Wolf-Hirschhorn syndrome candidate 2; Wolf-Hirschhorn syndrome candidate 2 homolog; Wolf-Hirschhorn syndrome candidate 2 protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7469
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9H3P2
• Gene Symbols: NELFA
• Immunogen: Recombinant Human WHSC2. Recombinant protein control fragment (Product #RP-104783).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov