Invitrogen™ WIBG Monoclonal Antibody (OTI1E10)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA526798

Catalog No. PIMA526798

Description

WIBG Monoclonal Antibody for Western Blot, IHC (P)

Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. [UniProt].

Specifications

• Antigen: WIBG
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9BRP8
• Gene Symbols: PYM1
• Immunogen: Full length human recombinant protein of WIBG produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1E10
• Conjugate: Unconjugated
• Gene: PYM1
• Gene Alias: A030010B05Rik; Partner of Y14 and mago; protein wibg homolog; PYM; PYM homolog 1 exon junction complex-associated factor; PYM homolog 1, exon junction complex associated factor; Pym1; RGD1306096; WIBG; within bgcn homolog; within bgcn homolog (Drosophila)
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84305
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid