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Invitrogen™ WISP2 Polyclonal Antibody
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Catalog No. FEPA5145020
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100 μL
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FEPA5145020 100 μL
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Catalog No. FEPA5145020 Supplier Invitrogen™ Supplier No. PA5145020
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RVEVLGKCCP EWVCGQGGGL GTQPLPAQGP QFSGLVSSLP PGVPCPEWST AWGPCSTTCG LGMATRVSNQ NRFCRLETQR RLCLSRPCPP SRGRSPQNSA Antigen sequence identity: Mouse 65%; Rat 65%.

Wisp2 a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. Wisp2 lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
TRUSTED_SUSTAINABILITY

Specifications

Antigen WISP2
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CCN5
Gene Accession No. O76076
Gene Alias CCN family member 5; CCN family protein COP-1; Ccn5; connective tissue growth factor-like protein; Connective tissue growth factor-related protein 58; Cop1; Crgr4; CT58; CTGFL; CTGF-L; Rcop1; UNQ228/PRO261; WISP2; WISP-2; WNT1 inducible signaling pathway protein 2; WNT1-inducible-signaling pathway protein 2
Gene Symbols CCN5
Host Species Rabbit
Immunogen Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 150-249. Recombinant protein control fragment (Product #RP-110102).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8839
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Format Liquid
Isotype IgG
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