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Invitrogen™ WISP2 Polyclonal Antibody
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Catalog No. PIPA5121104
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100 μL
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PIPA5121104 100 μL
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Catalog No. PIPA5121104 Supplier Invitrogen™ Supplier No. PA5121104
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Description

Rabbit Polyclonal Antibody

Positive test controls include: SKOV3, A-549, U2OS, Mouse heart. The target is usually found in the following locations: Secreted. Immunogen sequence: GQGGGLGTQP LPAQGPQFSG LVSSLPPGVP CPEWSTAWGP CSTTCGLGMA TRVSNQNRFC RLETQRRLCL SRPCPPSRGR SPQNSAF.

Wisp2 a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. Wisp2 lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
TRUSTED_SUSTAINABILITY

Specifications

Antigen WISP2
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.75 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene CCN5
Gene Accession No. O76076, Q9JHC6, Q9Z0G4
Gene Alias CCN family member 5; CCN family protein COP-1; Ccn5; connective tissue growth factor-like protein; Connective tissue growth factor-related protein 58; Cop1; Crgr4; CT58; CTGFL; CTGF-L; Rcop1; UNQ228/PRO261; WISP2; WISP-2; WNT1 inducible signaling pathway protein 2; WNT1-inducible-signaling pathway protein 2
Gene Symbols CCN5
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 164-250 of human WISP2 (NP_0038721).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22403, 29576, 8839
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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