Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Tocris Bioscience™ Withaferin A
Inhibits NF-κB activation
Supplier: Tocris Bioscience™ 2816/1
This item is not returnable. View return policy
SDSDocumentsProduct Certifications Promotions
DescriptionWithaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Withaferin A inhibits endothelial cells (HUVEC) sprouting in vitro (IC50 = 12 nM) and in vivo, prevents NF-κB activation by inhibiting activation of IKKβ and inhibits chymotrypsin-like activity of the 20S proteasome. In an animal model of Huntington's disease (HD), Withaferin A delays disease progression and increases lifespan; in a cellular model it suppresses aggregation of mutant huntingtin, activates HSF1 and induces Hsp70 chaperone expression.
|Store at -20°C|
Provide Content Correction
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok
For Research Use Only