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Tocris Bioscience™ Withaferin A
SDP

Catalog No. 28161R Shop All R&D Systems Products
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28-161-R 1mg
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Catalog No. 28-161-R Supplier Tocris Bioscience™ Supplier No. 2816/1
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Description

Inhibits NF-κB activation

Withaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Withaferin A inhibits endothelial cells (HUVEC) sprouting in vitro (IC50 = 12 nM) and in vivo, prevents NF-κB activation by inhibiting activation of IKKβ and inhibits chymotrypsin-like activity of the 20S proteasome. In an animal model of Huntington's disease (HD), Withaferin A delays disease progression and increases lifespan; in a cellular model it suppresses aggregation of mutant huntingtin, activates HSF1 and induces Hsp70 chaperone expression.

Specifications

Quantity 1 mg
Product Type Withaferin A
Purity >98%
Molecular Weight (g/mol) 470.6
Inhibitors Withaferin A

For Research Use Only

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