Tocris Bioscience™ Withaferin A

Description

Inhibits NF-κB activation

Withaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Withaferin A inhibits endothelial cells (HUVEC) sprouting in vitro (IC50 = 12 nM) and in vivo, prevents NF-κB activation by inhibiting activation of IKKβ and inhibits chymotrypsin-like activity of the 20S proteasome. In an animal model of Huntington's disease (HD), Withaferin A delays disease progression and increases lifespan; in a cellular model it suppresses aggregation of mutant huntingtin, activates HSF1 and induces Hsp70 chaperone expression.

Specifications

• Quantity: 1 mg
• Product Type: Withaferin A
• Purity: >98%
• Molecular Weight (g/mol): 470.6
• Inhibitors: Withaferin A

For Research Use Only