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  5. Tocris Bioscience™ WM 1119

Tocris Bioscience™ WM 1119
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Catalog No. 669250
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Catalog No. Quantity
66-925-0 50 mg
66-921-0 10 mg
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Catalog No. 66-925-0 Supplier Tocris Bioscience™ Supplier No. 6692/50
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Description

High affinity KAT6A (MOZ) competitive inhibitor

WM 1119 is a high affinity and competitive lysine acetyltransferase 6A (KAT6A/MOZ) inhibitor (Kd = 2 nM), which displays >250-fold affinity for KAT6A compared to KAT5 and KAT7. WM 1119 induces cell-cycle exit and cellular senescence, and inhibits growth of B-cell lymphoma cells in vitro (IC50 = 0.25 μM). WM 1119 also reduces H3K9ac in tumor cells, and decreases tumor burden and spleen weight in a mouse lymphoma model.

Specifications

Chemical Name or Material 2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide
CAS 2055397-28-7
Quantity 50 mg
Molecular Formula C18H13F2N3O3S
Formula Weight 389.38
Purity 98%
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