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Invitrogen™ WNK2 Polyclonal Antibody
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Catalog No. PIPA537108
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100 μL
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Catalog No. Quantity
PIPA537108 100 μL
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Catalog No. PIPA537108 Supplier Invitrogen™ Supplier No. PA537108
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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 243 kDa. Purity is >95% by SDS-PAGE.

WNK2 is a serine/threonine kinase involved in signal transduction and cellular communication. WNK kinases contain a lysine upstream of the traditional position, within a glycine string. This lysine functions as an anchor and orients ATP through interactions with the alpha and beta phosphoryl groups. The catalytic domains of WNK2, WNK3 and WNK4 are 95% homologous to WNK1. The human WNK1 gene encodes a 2,382 amino acid protein that is primarily expressed in heart, kidney, muscle and distal nephron. The human WNK3 gene encodes a protein that is primarily expressed in brain; the human WNK4 gene encodes a 1,243 amino acid protein that is expressed in kidney. Aberrant function of WNK kinases and their associated signaling pathways are implicated in hypertension, increased renal salt reabsorption and impaired K+ and H+ excretion.
TRUSTED_SUSTAINABILITY

Specifications

Antigen WNK2
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene WNK2
Gene Accession No. Q3UH66, Q9Y3S1
Gene Alias 1810073P09Rik; Antigen NY-CO-43; AW122246; ESTM15; Kiaa1760; kinase deficient protein; LOW QUALITY PROTEIN: serine/threonine-protein kinase WNK2; mitogen-activated protein kinase kinase kinase; mKIAA1760; NY-CO-43; P/OKcl.13; PRKWNK2; protein kinase lysine-deficient 2; Protein kinase with no lysine 2; protein kinase, lysine deficient 2; RGD1307284; SDCCAG43; Serine/threonine-protein kinase WNK2; serologically defined colon cancer antigen 43; WNK lysine deficient protein kinase 2; Wnk2; X83337
Gene Symbols WNK2
Host Species Rabbit
Immunogen A synthetic peptide corresponding to residues in human WNK2.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 306811, 65268, 75607
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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