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  5. Tocris Bioscience™ Wnt-C59

Tocris Bioscience™ Wnt-C59
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Catalog No. 514810
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Catalog No. Quantity
51-481-0 10 mg
51-485-0 50 mg
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Catalog No. 51-481-0 Supplier Tocris Bioscience™ Supplier No. 5148/10
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Description

Highly potent PORCN inhibitor

Wnt-C59 is a highly potent inhibitor of MBOAT (membrane-bound O-acyltranferase) family member Porcupine (PORCN) (IC50 = 74 pM) that mediates WNT palmitoylation and secretion. Wnt-C59 potently inhibits the processing of both canonical (1, 2, 3a, 6, 7b, 8a, 9a, 9b, 10) and non-canonical (4, 5a, 11, 16) Wnt subtypes. Wnt-C59 blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/β-catenin target genes. Wnt-C59 treated tumors show a decrease in β-catenincatenin, CyclinD1 and c-Myc. Wnt-C59 induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021 (Cat. No. 4423). Wnt-C59 efficiently induces neural differentiation of CTIP2+/COUP-TF1- cells from PSCs in culture. When grafted into the cortex of adult mice, develop abundant axonal fiber extension toward the spinal cord. Cell permeable and orally bioavailable.

Specifications

Quantity 10 mg
Product Type Wnt-C59
Purity >99%
Molecular Weight (g/mol) 379.45
Inhibitors Wnt-C59

For Research Use Only

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