Invitrogen™ WNT4 Monoclonal Antibody (55010)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA524376

Catalog No. PIMA524376

Description

Reconstitute at 0.5 mg/mL in sterile PBS.

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.

Specifications

• Antigen: WNT4
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: P22724, P56705
• Gene Symbols: Wnt4
• Immunogen: E. coli-derived recombinant mouse Wnt-4 (aa 37-76 and 222-295).
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Clone: 55010
• Conjugate: Unconjugated
• Gene: Wnt4
• Gene Alias: protein Wnt-4; SERKAL; signal molecule; UNQ426/PRO864; wingless-related MMTV integration site 4; wingless-type MMTV integration site family member 4; wingless-type MMTV integration site family, member 4; Wnt family member 4; WNT4; Wnt-4
• Host Species: Rat
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 22417, 54361
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized