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Invitrogen™ WNT4 Polyclonal Antibody
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Catalog No. PIPA596818
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100 μL
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PIPA596818 100 μL
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Catalog No. PIPA596818 Supplier Invitrogen™ Supplier No. PA596818
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FAVTRACSSG ELEKCGCDRT VHGVSPQGFQ WSGCSDNIAY GVAFSQSFVD VRERSKGASS SRALMNLHNN EAGRKAILTH MRVECKCHGV SGSCEVKTCW RAVPPFRQVG HALKEKFDGA TEVEPRRVGS SRALVPRNAQ FKPHTDEDLV YLEPSPDFCE QDMRSGVLGT RGRTCNKTSK AIDGCELLCC GRGFHTAQVE LAERCSCKFH WCCFVKCRQC QRLVELHTCR; Positive Samples: A-549, MCF7; Cellular Location: extracellular matrix, extracellular space.

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen WNT4
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.72 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Wnt4
Gene Accession No. P22724, P56705, Q9QXQ5
Gene Alias protein Wnt-4; SERKAL; signal molecule; UNQ426/PRO864; wingless-related MMTV integration site 4; wingless-type MMTV integration site family member 4; wingless-type MMTV integration site family, member 4; Wnt family member 4; WNT4; Wnt-4
Gene Symbols Wnt4
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 122-351 of human WNT4 (NP_1103882).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22417, 54361, 84426
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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