Invitrogen™ WNT4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596818

Catalog No. PIPA596818

Description

Immunogen sequence: FAVTRACSSG ELEKCGCDRT VHGVSPQGFQ WSGCSDNIAY GVAFSQSFVD VRERSKGASS SRALMNLHNN EAGRKAILTH MRVECKCHGV SGSCEVKTCW RAVPPFRQVG HALKEKFDGA TEVEPRRVGS SRALVPRNAQ FKPHTDEDLV YLEPSPDFCE QDMRSGVLGT RGRTCNKTSK AIDGCELLCC GRGFHTAQVE LAERCSCKFH WCCFVKCRQC QRLVELHTCR; Positive Samples: A-549, MCF7; Cellular Location: extracellular matrix, extracellular space.

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.

Specifications

• Antigen: WNT4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Wnt4
• Gene Alias: protein Wnt-4; SERKAL; signal molecule; UNQ426/PRO864; wingless-related MMTV integration site 4; wingless-type MMTV integration site family member 4; wingless-type MMTV integration site family, member 4; Wnt family member 4; WNT4; Wnt-4
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22417, 54361, 84426
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.72 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P22724, P56705, Q9QXQ5
• Gene Symbols: Wnt4
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 122-351 of human WNT4 (NP_1103882).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov