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Tocris Bioscience™ WNTinib
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Catalog No. 810650
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Catalog No. Quantity
81-065-0 50 mg
81-061-0 10 mg
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Catalog No. 81-065-0 Supplier Tocris Bioscience™ Supplier No. 8106/50
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Description

Inhibitor of mutant β-catenin signaling in hepatocellular carcinoma

WNTinib is a multi-kinase inhibitor with selectivity for mutant β-catenin (CTNNB1) in hepatocellular carcinoma compared to wild type hepatocytes (IC50 ranges are 0.36 μM-0.54 μM in primary organoids; 0.28 μM-1 μM in primary human HCC cell lines and 0.45 μM-2.3 μM in human cell lines ). Also inhibits VEGFR2, PDE6D and VEGFR1 (IC50 values are 0.3 μM, 0.3 μM and 0.6 μM respectively). Downregulates WNT and phospho-EZH2, upregulates trimethylation of H3K27 and normalises expression of apoptotic genes.

Specifications

Chemical Name or Material 4-[3-Fluoro-4-[[[[4-(1,1,2,2,2-pentafluoroethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
CAS 2770091-44-4
Quantity 50 mg
Target beta-Catenin
Molecular Formula C22H16F6N4O3
Purity 0.98
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