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  5. Tocris Bioscience™ WS 383

Tocris Bioscience™ WS 383
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Catalog No. 705550
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent, selective and reversible DCN1-UBC12 interaction inhibitor

WS 383 is a potent and reversible DCN1-UBC12 interaction inhibitor (IC50 = 11 nM). The compound displays selectivity for DCN1-UBC12 over inhibition of a panel of kinases. including Bruton's tyrosine kinase (BTK), cyclin-dependent kinases (CDKs) and epidermal growth factor receptor (EGFR). In vitro, WS 383 selectively inhibits cullin-3 neddylation over other cullins, and induces accumulation of p21, p27 and NRF2.

Specifications

Chemical Name or Material 5-[[2-[[(4-Chlorophenyl)methyl]thio]-5-methyl[1,2,4 ]triazolo[1,5-a]pyrimidin-7-yl]thio]-N,N-dimethyl-1 H-tetrazole-1-ethanamine hydrochloride
CAS 2247544-02-9
Quantity 50 mg
Target Ubiquitin Ligase (E3) Inhibitors
Molecular Formula C18H20ClN9S2.HCl
Purity 0.98
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