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  6. WT1 Antibody (WT1/857 + 6F-H2) - Azide and BSA Free, Novus Biologicals™

WT1 Antibody (WT1/857 + 6F-H2) - Azide and BSA Free, Novus Biologicals™
SDP

Catalog No. p-7105845 Shop All R&D Systems Products
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0.2 mg
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Catalog No. Quantity
NBP247858A 0.1 mg
NBP247858B 0.2 mg
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Catalog No. NBP247858A Supplier Novus Biologicals Supplier No. NBP2478580.1MG
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Description

Mouse Monoclonal Antibody

WT1 Monoclonal specifically detects WT1 in Human, Mouse, Rat samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin, CyTOF-ready.

Specifications

Antigen WT1
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence, CyTOF
Classification Monoclonal
Clone WT1/857 + 6F-H2
Concentration 1.0 mg/mL
Conjugate Unconjugated
Dilution Flow Cytometry : 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin : 0.5 - 1.0 ug/ml, Immunofluorescence : 0.5 - 1.0 ug/ml, CyTOF-ready
Formulation PBS with No Preservative
Gene Alias AWT1, NPHS4GUD, WAGR, Wilms tumor 1, Wilms tumor protein, WIT-2, WT33
Gene Symbols WT1
Host Species Mouse
Immunogen Recombinant full length human WT1 protein (WT1/857); Recombinant fragment aa1-181 of human WT1 (6F-H2)
Purification Method Protein A or G purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Angiogenesis, Cancer, Cell Cycle and Replication, Cellular Markers, Chromatin Research, Tumor Suppressors
Primary or Secondary Primary
Gene ID (Entrez) 7490
Test Specificity Recognizes a 47-55kDa-tumor suppressor protein, identified as Wilm's Tumor (WT1) protein. The antibody reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, frequently found in subsets of sporadic Wilm s tumors.WT1, a sporadic and familial pediatric kidney tumor, is genetically heterogeneous. Wilm s tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm s tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor. Lung adenocarcinomas rarely stain positive with this antibody. WT1 protein expression in mesothelial cells has become a reliable marker for the diagnosis of mesotheliomas.
Target Species Human, Mouse, Rat
Content And Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Form Purified
Isotype IgG1 κ
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