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Invitrogen™ WT1-AS Polyclonal Antibody
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Catalog No. PIPA5103316
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PIPA5103316 100 μL
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Catalog No. PIPA5103316 Supplier Invitrogen™ Supplier No. PA5103316
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total WIT1.

Wilms' tumor is a neoplasm of the kidneys that usually occurs in children and is characterized by the presence of abortive tubules and glomeruli surrounded by a spindled cell stroma. The 11p13 Wilms' tumor locus consists of two coordinately regulated transcripts, WT1 and WIT-1, which are mutated in Wilms' tumors. Wilms' tumor upstream neighbor 1 (WIT-1) is encoded by an intron-less gene upstream of the Wilms' tumor 1 (WT1) gene, which is is important for nephrogenesis and gonadal growth. The WT1 gene is bi-directionally transcribed from the same promoter region as WIT-1, which may function as an antisense regulator of WT1. WIT-1 and WT1 have the same temporal and cell-restricted expression pattern, although the expression of WIT-1 is less abundant. Methylation of the WIT-1 gene is implicated in hematologic malignancy of chemoresistant acute myeloid leukemia. Single nucleotide polymorphisms (SNPs) in the WIT-1 gene are significantly associated with focal segmental glomerulosclerosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen WT1-AS
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene WT1-AS
Gene Accession No. Q06250
Gene Alias 6030498F17; AI314831; Wilms tumor 1 homolog, opposite strand; WIT1; WIT-1; WT1 antisense RNA; WT1AS; Wt1-as; WT1-AS1; Wt1os
Gene Symbols WT1-AS, Wt1os
Host Species Rabbit
Immunogen A synthesized peptide derived from human WT1-AS(Accession Q06250), corresponding to amino acid residues V12-E62.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 329480, 51352
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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