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Invitrogen™ WTAP Monoclonal Antibody (OTI6H3)
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Catalog No. PIMA526971
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100 μL
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PIMA526971 100 μL
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Catalog No. PIMA526971 Supplier Invitrogen™ Supplier No. MA526971
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Description

Mouse Monoclonal Antibody

WTAP Monoclonal Antibody for Western Blot, IHC (P)

Wilms' tumor (WT) is an embryonal malignancy of the kidney that affects 1 in 10,000 infants and is observed in both sporadic and inherited forms. The Wilms' tumor protein (WT1) binds the DNA sequence GCGGGGGCG, a recognition element common to the early growth response (Egr) family of Zn2+ finger transcriptional activators, and functions as a transcriptional repressor. WTAP (Wilms tumor 1-associating protein) is a ubiquitously expressed nuclear protein that interacts with WT1 and may be involved in regulating mRNA splicing. WTAP is found in nuclear speckles, where it regulates the G2/M cell cycle transition by binding to the 3' UTR of cyclin A2, thus enhancing its stability. Additionally, WTAP inhibits expression of WT1 target genes and is able to impair the ability of WT1 to bind DNA. Two isoforms of WTAP exist due to alternative splicing events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen WTAP
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI6H3
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene WTAP
Gene Accession No. Q15007
Gene Alias 2810408K05Rik; 9430038B09Rik; Female-lethal(2)D homolog; hFL(2)D; KIAA0105; Mum2; PNAS-132; pre-mRNA-splicing regulator WTAP; putative pre-mRNA splicing regulator female-lethal(2D); RGD1563824; Wilms tumor 1 associated protein; wilms tumor 1-associating protein; Wilms' tumour 1-associating protein; Wilms tumour 1-associating protein; WT1-associated protein; WTAP
Gene Symbols WTAP
Host Species Mouse
Immunogen Human recombinant protein fragment corresponding to amino acids 2-106 of WTAP produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9589
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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