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MilliporeSigma™ WTAP, Rabbit, Unlabeled, Polyclonal,

Catalog No. ABE555 Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
ABE555 100 μL Unconjugated
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Description

Rabbit Polyclonal Antibody

Pre-mRNA-splicing regulator WTAP (UniProt Q15007; also known as Female-lethal (2)D homolog, hFL(2)D, Wilms tumor 1-associating protein, WT1-associated protein) is encoded by the WTAP (also known as KIAA0105) gene (Gene ID 9589) in human. WTAP is an ubiquitously expressed nuclear protein that is localized throughout the nucleoplasm and in speckles and partially co-localizes with splicing factors. A mouse homolog has also been reported that shares 96% sequence identity. WTAP regulates G2/M cell-cycle transition by binding to the 3&prime UTR of CCNA2, which enhances its stability. WTAP knockdown is shown to induce G2 accumulation, which is partially rescued by adenoviral overexpression of cyclin A2. WTAP-null mice exhibit proliferative failure with early embryonic death. WTAP is also reported to be an oncogenic protein in acute myeloid leukemia (AML) and its increased expression has been linked to chemoresistance in AML. Ref: Horiuchi, K., et al. (2006), Proc. Natl. Acad. Sci. USA 103, 17278-17283. Bansal, H., et al. (2014). Leukemia 28, 1171-1174.
TRUSTED_SUSTAINABILITY

Specifications

Antigen WTAP
Applications Western Blot
Classification Polyclonal
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene WTAP, KIAA0105
Gene Accession No. Q15007
Host Species Rabbit
Immunogen KLH-conjugated linear peptide corresponding to an internal sequence within the N-terminal half of human WTAP.
Purification Method Affinity Purified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Epigenetics & Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_001257460
Test Specificity This polyclonal antibody targets an internal sequence within the N-terminal half of human WTAP.
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
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For Research Use Only. Not for use in diagnostic procedures.

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