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Invitrogen™ WTIP Polyclonal Antibody
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Catalog No. PA548292
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400 μL
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Catalog No. Quantity
PA548292 400 μL
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Catalog No. PA548292 Supplier Invitrogen™ Supplier No. PA548292
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Description

Rabbit Polyclonal Antibody

Predicted to react with mouse based on sequence homology.

Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture. In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body. Involved in cilia growth and positioning. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen WTIP
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.35 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene WTIP
Gene Accession No. A6NIX2
Gene Alias Wilms tumor 1 interacting protein; Wilms tumor protein 1-interacting protein; WT1-interacting protein; WTIP
Gene Symbols WTIP
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 243-271 amino acids of human WTIP.
Purification Method Antigen affinity chromatography, Protein A
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 126374
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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